Insulin resistance and selection of antihypertensive drug. Insulin hypothesis of hypertension. Pro.
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منابع مشابه
Insulin Resistance and Hypertension
Insulin resistance refers to the reduction in insulinmediated glucose uptake in insulin-sensitive tissues, specifically in skeletal muscle. As a compensatory response, hyperinsulinemia ensues to maintain normal blood glucose levels. In epidemiological studies, fasting insulin level is commonly used as a surrogate marker of insulin resistance. In normoglycemic subjects, fasting insulin correlate...
متن کاملInsulin resistance and hypertension.
A common mechanism which may be involved in the development of hypertension in both type I and type II diabetes mellitus is a deficiency of insulin at the cellular level. Observations from a number of laboratories suggest that impaired cellular response to insulin rather than hyperinsulinemia predisposes to increased vascular smooth muscle tone (the hallmark of hypertension in the diabetic stat...
متن کاملInsulin resistance and hypertension: the Insulin Resistance Atherosclerosis study.
The association between insulin resistance and insulinemia and hypertension is controversial. We examined the relation between insulin resistance and hypertension in 564 non-Hispanic whites (NHW), 505 Hispanics (H), and 413 African Americans (AA) who participated in the Insulin Resistance Atherosclerosis Study (IRAS). Insulin sensitivity was measured with a frequently sampled intravenous glucos...
متن کاملImplications for the Insulin Hypothesis of Hypertension
The last several years have witnessed tremendous interest in the hypothesis that insulin resistance and hyperinsulinemia contribute to the pathogenesis of hypertension. This hypothesis was stimulated by epidemiological studies that demonstrated an association between obesity, insulin resistance, and hypertension.Subsequent studies suggested that even lean individuals with essential hypertension...
متن کاملObesity, hypertension, and insulin resistance.
1 T his article summarizes material presented at the meeting of the American Society of Hypertension (ASH) in New York, New York, May, 2002, as well as presentations at the American Diabetes Association (ADA) Annual Meeting in San Francisco, California, June, 2002. At a symposium addressing the relationships between obesity, hypertension, and cardiovascular disease at the ASH, Roger Unger (Dall...
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ژورنال
عنوان ژورنال: Rinsho yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics
سال: 1996
ISSN: 1882-8272,0388-1601
DOI: 10.3999/jscpt.27.375